Company News
4 - 8 December 2011
Dubai
United Arab Emirates
Dr.Marcus Hompesch
President - CEO, Profil Institute for Clinical Research
Corporate Chairman
Step Out: Walk to STOP Diabetes
On behalf of the team at Profil Institute for Clinical Research, I am honored and proud to be the 2011 Corporate Chairperson for the American Diabetes Association’s Step Out: Walk to STOP Diabetes in San Diego.
The ADA is one of the strongest advocates for patients with Diabetes, in particular in supporting scientific excellence and research programs, hence supporting progress towards better treatments of the disease.
On behalf of the millions of patients with Diabetes the ADA is also one of the most active lobbyists in the political and medical care arena, committed to improve the life of every patient with Diabetes, ~ 24 million in the US alone. Considered that projections tell us that in just a few years from now 1 out of 3 kids is expected to develop Diabetes, everyone can understand immediately why it is in our own best interest as a nation and as businesses to not only support the ADA but in essence to join forces with the American Diabetes Association in the fight against Diabetes, and for better treatments.
I would like to invite you to join me for the 2011 ADA -
Step Out: Walk to STOP Diabetes
Sunday, October 23, 2011
De Anza Cove at Mission Bay, San Diego.
All of us are well advised to contribute and mobilize in the fight against Diabetes.
Join our Profil 4 fun Team. You will not be sorry!
12 - 16 September 2011
Lisbon
Portugal
Booth # D.32
Poster Event B, Tuesday, 13:30 - 14:30
PS 092 Insulin therapy in type 1 diabetes
1043 Accelerated absorption and reduced glycaemic variability in type 1 diabetes mellitus patients by human hyaluronidase-facilitated coinfusion of a prandial insulin analogue
M. Hompesch, D.B. Muchmore, L. Morrow, D.E. Vaughn
Poster Event C, Wednesday, 12:30 - 13:30
PS 075 The three G's: Glucokinase, Glucagon receptors and G-protein coupled receptors
884 Intact central counter-regulatory responses to hypoglycaemia induced by oral glucokinase activators in comparison with insulin infusion in healthy male volunteers
E. Norjavaara, H. Ericsson, F. Sjoberg, M. Leonsson-Zachrisson, L. Morrow, M. Hompesch
885 AZD1656, a novel glucokinase activator, lowers plasma glucose in patients with type 2 diabetes
L. Morrow, M. Leonsson-Zachrisson, H. Ericsson, M. Wollbratt, M. Knutsson, M. Hompesch, E.Norjavaara
24 - 28 June 2011
San Diego, CA
USA
Booth # 2113
Profil Institute's posters and publications
- Sitagliptin and Metformin Decrease Plasma Glucose by Complementary Mechanisms
in Treatment-Naïve Patients with Type 2 Diabetes
E. Migoya, L. Morrow, M. Gutierrez, J. Miller, W.-L. Luo, E. O'Neill, A. Stoch, J.A. Wagner
Pharmacologic Treatment of Diabetes-DPP-4 Inhibitors:
Monday, June 27, 2011; 1:00 PM-2:00 PM
Hall B, Abstract No. 0980-P; Guided Audio Tour Poster
General Poster Session I:
Saturday, June 25; 11:30AM-1:30 PM
- Human Hyaluronidase Coinjection Consistently Accelerates Prandial Insulin
Pharmacokinetics (PK) and Glucodynamics (GD) Across Studies and Populations
D.Muchmore, M. Hompesch, L. Morrow, D. Vaughn
Pharmacologic Treatment of Diabetes– Insulin Therapies:
Sunday, June 26, 2011; 1:00 PM-2:00 PM
Hall B, Abstract No. 0965-P; Guided Audio Tour Poster
General Poster Session I:
Saturday, June 25; 11:30AM-1:30 PM
- Addition of Human Hyaluronidase to Rapid Analog Insulin Reduces the Absolute Variability of Early Insulin Absorption across Infusion Set Life
L. Morrow, D. Muchmore, M. Hompesch, D. Vaughn
General Poster Session II:
Sunday, June 26; 12:00 PM-2:00 PM
Hall B, Abstract No. 0027-LB
- Recovery from Hypoglycemia in Healthy Subjects is Preserved Despite Glucagon Receptor Blockade by MK-0893
M. Troyer, M. Hompesch, B. Pramanik, W. Zheng, K. Win, S. Dunbar, S. Li, M. Ruddy, J. Amatruda, K. Kaufman, J. Wagner, S. Aubrey Stoch
General Poster Session II:
Sunday, June 26; 12:00 PM-2:00 PM
Hall B, Abstract No. 0494-P
- Recovery from Hypoglycemic Clamp in Type 2 Diabetes (T2DM) Patients
during β-Adrenergic Blockade Plus Glucagon Receptor Blockade with MK-0893
M. Troyer, M. Hompesch, T. Jax, B. Pramanik, F. Liu, L. Morrow, K. Win, T. Reynders, C.-C. Liu,
S. Engel, T. Heise, E. Maliwat, W. Denney, D. Kelley, J. Wagner, S. Aubrey Stoch
General Poster Session II:
Sunday, June 26; 12:00 PM-2:00 PM
Hall B, Abstract No. 0495-P
- Triglyceride to HDL Cholesterol ratio and Systolic Blood Pressure:
Potential Markers for NAFLD in Patients with Type 2 Diabetes
C. Alderson, L. Morrow, S. Lindsay
Abstract No. 2509-PO
- Effects of Trial Enrollment on Metabolic Control in Subjects with Type 2 Diabetes: Is There a “Study Effect”?
R. Schott, D. Hill, L. Morrow, K. Schott, M. Hompesch
Abstract No. 2271-PO
- Additional Glucose-Lowering Effects of the Oral GK Activator, MK-0941,
in Patients with T2DM on Basal Insulin
E. Migoya, J. Miller, M. Moreau, C. Reitman, L. Maganti, P. Larson, M. Gutierrez, L. Morrow,
E. Denoia, K. Gottesdiener, J. Wagner
Abstract No. 2234-PO
Profil Institute is proud to announce again our team of local riders -
"Profil Peddlers" at the Tour de Cure this May 7.
The Tour de Cure is a bicycle ride to raise money for the American Diabetes Association.
Each location’s ride routes are designed for everyone from the occasional rider to the experienced cyclist.
Cyclists of all levels of expertise are sure to enjoy this unique day of fun, fitness, friendship and the personal satisfaction of completing a ride that moves us closer to finding a better treatment for Diabetes.
Profil Institute is close to reaching our goal of 40 riders on a team comprised of employees and community friends.
Additionally, Profil Peddlers are striving towards collecting donations totaling $15,000
as a Corporate team.
Our very own CFO, Claus Hakenesch, is San Diego’s 2011 Public Relations Committee Chairperson for the event and is passionately engaging team members on regular training rides.
The San Diego Tour de Cure is looking forward to having 1,500 cyclists at the event this year and Profil Institute is proud to be a strong participant as a sponsor, as a team, and as volunteers.
Whether you are a first-time rider or an avid cyclist, the Tour de Cure has a route that is perfect for you.
Take the ride of your life! Join our team! Profil Peddlers
Profil Institute is proud to give Title Sponsorship to Glucomotive's team at the Carlsbad Marathon on January, 23, 2011.
With over 80 runners, including some of our own employees, Glucomotive will make an impact at this sold-out event!
Their goal is to triple Insulindependence's youth mentor programs in 2011 with the funds they raise through this upcoming weekend.
Part of Profil Institute's Title Sponsorship will also fund a Triabuddy, a program focusing on youth outreach and fostering leadership development in the Diabetes multi-sport community.
Conference Theme:
"Advances in Translational Research and Development"
1 - 4 February 2011
Zydus Research Centre, Ahmedabad
India
Session
- Should Safety, Drug Exposure and Clinical Efficacy of Diabetes Drugs be Assessed in Patients or in Healthy Volunteers
Dr. Marcus Hompesch
Friday, February 4, 09:45 - 10:30 AM.
Conference Theme: Potential to Perfection
11 - 12 February 2011
Hotel "Crowne Plaza Today", Gurgaon
India
Booth in the Exhibitor hall
Session
- Early Clinical Development in India - Proof of Concept
Dr. Marcus Hompesch
Friday, February 11, 11:30 - 1:00 p.m.
2 - 5 March 2011
Dallas, TX
USA
Booth # 520
Dr.Marcus Hompesch
President - CEO, Profil Institute
Corporate Chairman
Step Out: Walk to Fight Diabetes
On behalf of the team at Profil Institute for Clinical Research, I am honored and proud to be the 2010 Corporate Chairperson for the American Diabetes Association’s Step Out: Walk to Fight Diabetes in San Diego.
Congratulations, Profil4funTeam Members! Thank you for your outstanding support in the fight against Diabetes!
Our team raised an amazing total of more than $10,000!
Because of your hard work and dedication, we continue making a difference in the lives of more than 23 million Americans living with Diabetes.
Please check out our Team Page for a full update on our Step Out: Walk to Fight Diabetes experience!
http://main.diabetes.org/goto/profil4fun
The ADA is one of the strongest advocates for patients with Diabetes, in particular in supporting scientific excellence, research programs and patient education, hence supporting progress towards better treatments of the disease.
Fight against Diabetes - One step at a time.
Dr.Marcus Hompesch
President - CEO, Profil Institute
Corporate Chairman
Step Out: Walk to Fight Diabetes
On behalf of the team at Profil Institute for Clinical Research, I am honored and proud to be the 2010 Corporate Chairperson for the American Diabetes Association’s Step Out: Walk to Fight Diabetes in San Diego.
The ADA is one of the strongest advocates for patients with Diabetes, in particular in supporting scientific excellence and research programs, hence supporting progress towards better treatments of the disease.
On behalf of the millions of patients with Diabetes the ADA is also one of the most active lobbyists in the political and medical care arena, committed to improve the life of every patient with Diabetes, ~ 24 million in the US alone. Considered that projections tell us that in just a few years from now 1 out of 3 kids is expected to develop Diabetes, everyone can understand immediately why it is in our own best interest as a nation and as businesses to not only support the ADA but in essence to join forces with the American Diabetes Association in the fight against Diabetes, and for better treatments.
I would like to invite you to join me for the 2010 ADA - Champions for a Cure Step Out: Walk to Fight Diabetes
Sunday, October 24, 2010.
All of us are well advised to contribute and mobilize in the fight against Diabetes.
Join our Profil Team. You will not be sorry!
20 - 24 September 2010
Stockholm, Sweden
Booth: # B.01.20
Profil's Oral Presentation
-
Improved glycemic variability in T1DM and T2DM patients by coinjection of prandial Insulin analog with human hyaluronidase
Marcus Hompesch, Douglas Muchmore, Linda Morrow,
Elizabeth Ludington, and Daniel Vaughn
Tuesday, September 21, 10:45 a.m. - 12:15 p.m.
Session: OP 01 Novel formulations and delivery of Insulin, Nobel hall
Profil's Posters
-
Comparative Pharmacokinetics and Pharmacodynamics of High-Dose Human Regular U-500 Insulin versus Human Regular U-100 Insulin in Healthy Obese Subjects
H. Linnebjerg, A. de la Peña, L.A. Morrow, H.H. Jiang, K. Win,
L.L. Wolka, M. Hompesch, M. Riddle, J.A. Jackson
Thursday, September 23, 12:30 p.m. - 1:30 p.m., Poster Event E
Poster No.# 964
-
More rapid onset and shorter duration of Insulin exposure and action for 3 rapid Insulin analogs coinjected with human hyaluronidase
Douglas Muchmore, Linda Morrow, Marcus Hompesch,
Elizabeth Ludington, and Daniel Vaughn
Thursday, September 23, 12:30 p.m. - 1:30 p.m., Poster Event E
Poster No.#965
-
Canagliflozin, A Novel Inhibitor of Sodium Glucose
Co-Transporter 2, Improved Glucose Control in Subjects with
Type 2 Diabetes: Results of a Phase 1b Study
P.L. Rothenberg, D. Devineni, A. Ghosh, D. Polidori, M. Hompesch,
S. Arnolds, L. Morrow, H. Spitzer, J. Blake, D. Wexler, Y. Tan,
K. Smulders, K. Demarest, S. Sha,
Tuesday, September 21, 12:30pm – 1:30pm, Poster Event A
Poster No.#876
-
Sitagliptin and Metformin Increase Active GLP-1 by Complementary Mechanisms in Treatment-naïve Patients with Type 2 Diabetes
E.M. Migoya1, J. Miller, W.-L. Luo, E. O'Neill, L. Morrow, M.J. Gutierrez, A. Stoch, J.A. Wagner
Tuesday, September 21, 12:30pm - 1:30pm, Poster Event A
Poster No.#818
19 - 20 August 2010
Bangalore, India
Panel Discussion
- Sourcing the right partners, Sponsors – vendor partnerships
Shashidhar Rao, R. Mohan, Marcus Hompesch
Friday, August 20, 12:00 p.m.
17 - 23 July 2010
Copenhagen, Denmark
Session
- Early Indications for Clinical Efficacy of Diabetes Drugs in Develpment in Phase 1 Studies: How?
Marcus Hompesch
Monday, July 19, 1:00 p.m. - 2:00 p.m.
Poster Hall, Poster Board No. Mon 175
25 - 29 June 2010
Orlando, Fl
Booth: # 1764
-
Human Hyaluronidase Coinjection Accelerates Insulin Pharmacokinetics and Glucodynamics of 3 Rapid Insulin Analogs
Linda Morrow, Douglas Muchmore, Marcus Hompesch, Elizabeth Luddington , Daniel Vaughn
Monday, June 28, 4:30 p.m. - 4:45 p.m.
Session: Insulin Delivery Systems, Room 311
- Coadministration of Liraglutide with Insulin Detemir Does Not Affect the Pharmacokinetics of Either Drug
Linda Morrow, Marcus Hompesch, Heidi Guthrie, Denise Chang, William Lyness, DJ Chatterjee
Abstract No. 834ADA10D1; Poster Hall C Publication No. 653-p
- Canagliflozin, a Novel Inhibitor of Sodium Glucose Co-transporter 2, Improved Glucose Control in Subjects with Type 2 Diabetes and Was Well Tolerated
Sue Sha, Damayanthi Devineni, Atalanta Ghosh, David Polidori, Marcus Hompesch, Sabine Arnolds, Linda Morrow, Heike Spitzer, Joanne Blake, David Wexler, Yvonne Tan, Kris Smulders, Keith Demarest, Paul Rothenberg
Abstract No. 2433ADA10D1; Poster Hall C Publication No. 568-p
- Canagliflozin Improves Glycemic Control in Subjects With Type 2 Diabetes (T2D) Not Optimally Controlled on Stable Doses of Insulin
Sherwyn Schwartz, Linda Morrow, Marcus Hompesch, Damayanthi Devineni, Donna Skee, An Vandebosch, Joe Murphy, Michael Pfeifer
Abstract No. 3223ADA10D1; Poster Hall C Publication No. 564-p
- Accelerated Insulin PK and Improved Glycemic Control in T2DM Patients by Coinjection of Prandial Insulin with Hyaluronidase
Marcus Hompesch, Douglas Muchmore, Linda Morrow, Elizabeth Luddington, Daniel Vaughn
Abstract No. 1445ADA10D1; Poster Hall C Publication No. 387-pp
- A Phase 1, Open-Label Study of the Effect of Albuterol or Fluticasone on the Pharmacokinetics of Inhaled Technosphere® Insulin Inhalation Powder in Healthy Subjects
Robert Baughman, James Cassidy, Nikhil Amin, Marcus Hompesch, Mark Marino, Pamela Haworth, Peter Richardson
Abstract No.1764ADA10D1; Poster Hall C Publication No. 528-p
- Human Regular Insulin U-500 Shows Prolonged Time-to-Peak Effect and Longer Duration of Action vs Human Regular Insulin U-100 in Healthy Obese Subjects
Jeffrey A. Jackson, Amparo de la Peña, Linda A. Morrow, Helle Linnebjerg, Honghua H. Jiang, Khin Win, Linda L. Wolka,
Marcus Hompesch, Matthew Riddle
Abstract No.248ADA10D1LB; Poster Hall C Publication No. 14-LB
- Sitagliptin and Metformin Increase Active GLP-1 by Complementary Mechanism in Treatment-Naive Patients with Type 2 Diabetes
Elizabeth Migoya, Jutta Miller, Wen-Lin Luo, Edward O'Neill,
Linda Morrow, Maria Gutierrez, Aubrey Stoch, John A. Wagner
Abstract No.1636ADA10D1; Poster Hall C Publication No. 0572-p
published January - July 2010
Tour de Cure 2010, San Diego
Congratulations, Team Profil Peddlers!
We joined hundreds of Red Riders who as patients with Diabetes share a similar story and showed what courage it takes to live with Diabetes.
We brought family, friends and co-workers to the Tour de Cure, San Diego on Saturday, April 17th .
Thank you for your outstanding support in the fight against Diabetes!
Our team raised an amazing total of more than $10,000 to help change the future of Diabetes. We had 31 Profil Peddlers and 10 volunteers!
Because of your hard work and dedication to the Profil team and the American Diabetes Association, we were able to make a difference in the lives of 23.6 million Americans living with Diabetes.
Thanks to the generosity and support of our contributors, the American Diabetes Association can fund much-needed community-based education programs, protect the rights of people with Diabetes and fund critical research for a cure.
Together we can find better treatments for Diabetes.
published April - July 2010
American Diabetes Association
"Team Profil" takes the Tour de Cure - Join us
The San Diego Tour de Cure boasts one of the most scenic and beautiful routes in California.
Cyclists of all levels of expertise are sure to enjoy this unique day of fun, fitness, friendship and the personal satisfaction of completing a ride that moves us closer to finding a better treatment for Diabetes.
All routes offer spectacular views of the ocean and mountain ranges of North County San Diego.
Whether you ride 30 miles or take on challenge of a full Century we are certain you will fall in love with San Diego all over again!
Profil is proud to announce a team of riders locally - "Team Profil"
Take the ride of your life! Join our team!
Whether you are a first-time rider or an avid cyclist, we have a route that is perfect for you.
For more information click here.
Hear the spot
published March-April 2010
ISCR 2010 presentation
At this year's annual meeting of the Indian Society for Clinical Research (ISCR) in Bangalore, India, on January 7-9, Dr. Marcus Hompesch gave an invited presentation on challenges during early phase cincial development of Diabetes drugs.
The presentation was very well received and led to interesting discussions with both academic researchers and scientists from the bio-pharmaceutical industry.
Historically, there has been very limited Phase I study work completed by Indian bio-pharmaceutical companies. However, with an increasing number of innovator compounds advancing from pre-clinical to clinical stage in India, there is growing interest in the early phase clinical research process. Of particular interest was the case study presented of a first-in-man study conducted in the disease population (Diabetes).
The presentation is available upon request,
please contact:
Profil Institute for Clinical Research Inc.
Dr. Marcus Hompesch
President – CEO
science@profil-research.com
published February 2010
As part of our mission to find better treatments for Diabetes and Obesity, we are proud to support others in our community who encourage lifestyle changes to improve their health.
One such organization is insulinDependence.org, whose mission is to inspire people with Diabetes to set personal fitness goals, educate them on adaptive management strategies through hands-on experience, and equip them to explore their individual capacities.
We are sponsoring a group of Type I diabetics who participated in January's Carlsbad Marathon as Glucomotive, under the umbrella of insulinDependence. This is the second year we have partnered with this organization and we encourage you to join in supporting them.
Please click here for more information!
published January 2010
Profil scientists present internationally
Profil scientists have presented their work at several recent conferences, including the European Association for the Study of Diabetes (EASD) in Vienna, Austria, and the International Diabetes Federation (IDF) in Montreal, Quebec.
The most recent presentations were at the Diabetes Technology Meeting in San Francisco, CA and included three poster presentations:
1. Hompesch, Marcus, et al.
Evaluation of Performance of a Continuous Glucose Measurement Device in Subjects with Type 1 and Type 2 Diabetes by means of a Glucose Clamp (Hypoglycemia Performance Feasibility)
2. Judge, Kevin, et al.
Comparative Accuracy of Continuous Glucose Monitoring using Glucose Binding Protein (GBP) in a 12 hour Feasibility Study
3. Muchmore, Douglas, et al.
Reduced Variability of Insulin Lispro Injected with Hyaluronidase
and one oral presentation:
1. Judge, Kevin.
First Report of the Accuracy of Continuous Glucose Monitoring Using Glucose-Binding Protein (GBP).
For more details of these presentations, please contact:
Profil Institute for Clinical Research, Inc.
Dr. Linda Morrow
Medical Director – COO
profilnews@profil-research.com
published December 2009
Profil Plays Santa!
Profil's staff helped to spread holiday cheer by contributing to the Chula Vista Police Activities League annual Toy Drive.
In just two days, we were able to gather 92 new toys for the children of Chula Vista!
Additional cash donations were also raised for this especially deserving group in our own backyard.
 
published December 2009
Profil walkers raise over $ 2,000 for JDRF
(Juvenile Diabetes Research Foundation)
Be a part of the cure!
Team Profil participated in the JDRF Walk to Cure Diabetes on November 8th 2009 at the UCSD campus.
Team Profil was proud to be a part of the nearly 5,000 walkers - the largest walk in the history of JDRF San Diego!
Fundraising efforts by the teammates helped raise $1,075 to support JDRF's mission to cure Diabetes and its complications through the support of research.
The management team is proud to announce that we will match the money raised by our walkers.
published November 2009
RSSDI 2009 presentation
At this year's meeting of the Research Society for the Study of Diabetes in India (RSSDI), in Ahmedabad, India, Profil scientists presented a poster on the automated glucose clamp technique.
The poster presentation was perceived very well and led to interesting discussions with academic researchers and scientists from the bio-pharmaceutical industry.
The abstract that was submitted is available upon request,
please contact:
Profil Institute for Clinical Research Inc.
Dr. Marcus Hompesch
President – CEO
profilnews@profil-research.com
published November 2009
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