Methods of Research
Profil Institute’s Methods of Early Phase Clinical Research

Profil Institute for Clinical Research, Inc. uses a variety of state-of-the-art methods to perform complex metabolic research to understand the mechanism of action of a given compound and to demonstrate the mechanistic concept behind diabetes or obesity drugs in development.

Profil Institute’s metabolic assessment methods include:

  • Automated glucose clamps, including euglycemic, hyperglycemic, hypoglycemic and pancreatic clamps
  • Insulin sensitivity assessments
  • Islet cell function assessment, including graded glucose infusions
  • Metabolic pathway biomarkers
  • Oral and intravenous glucose tolerance tests
  • Tracer studies/endogenous glucose production and turnover (6, 6-D2-Gluc, U13-Gluc)
  • Body composition measurements
  • Energy expenditure, including indirect calorimetry & doubly labeled water
  • 24-hour blood pressure and Holter monitoring
  • Cardiac telemetry
  • Cognitive function testing and mood assessment
  • Food intake studies and precise meal planning
  • Satiety, appetite and hunger assessments
  • Tissue biopsies and tissue cultures
  • Spirometry

Profil Institute’s imaging methods include:

  • Bone densitometry (DEXA)
  • Bioimpedance
  • Echocardiography
  • Magnetic resonance imaging (MRI)
  • Magnetic resonance spectroscopy (MRS)
  • Computed tomography (CT)
  • Positron emission tomography (PET)
  • Fundus photography
  • Ultrasonography

Beyond methods that are specific for metabolic research, Profil Institute uses all standard research tools for early phase clinical research.  There is often a need to address overlapping aspects of these closely related conditions. This can be accomplished by combining investigative methods as appropriate.